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I can remember when The Simpsons premiered. It was outlawed by most parents, and thought by many to be the end of civilization as we know it (an honor that now belongs to the gays, apparently). While the show is certainly not reverent, it feels tame compared to many other shows on television today (such as its raunchy Fox cousin, Family Guy), and often continues to have a "moral of the story" narrative that endears it to me even today. While I seldom catch the brand new episodes that air on Sunday nights, last year's The Simpsons Movie had enough charm and humor to make me believe that there's still life in Springfield even after all these years.
Any other shows you'd like to see last 22 seasons?